The Close Cousins DNA Project – A Request for Help


Image by Aaron Logan

Roughly 6 million years ago, the Hominini subtribe of the Hominidae family tree (the so-called “great apes”) diverged into two known branches, with one branch (genus Pan ) resulting in modern-day Chimpanzees and Bonobos, and the other branch (genus Homo) resulting in modern-day humans.

Since there has only been 6 million years of divergent evolution, Chimpanzees/Bonobos and Humans share a great deal of DNA sequence in common (although estimates vary widely and typically depend on what, exactly, is being considered in the comparison).

The Close Cousins DNA Project

On May 31, 2008, the Close Cousins DNA Project was launched by Bill Davenport as a result of a discussion on the Genealogy-DNA mailing list regarding the relatedness of human and chimpanzee Y-DNA.  From the launching post:

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5th International Conference on Genetic Genealogy for Family Tree DNA Group Administrators

On March 14th and 15th of this year, Family Tree DNA hosted the 5th Annual Conference on Genetic Genealogy.  From the press release (pdf):

Each year, world renowned experts in genetics and science present cutting-edge developments and exciting new applications at this two-day educational forum which draws attendees from Family Tree DNA’s Group Administrators in North America and throughout the world. Among the speakers at the upcoming conference will be Dr. Spencer Wells, the director and population geneticist heading the National Geographic’s landmark Genographic Project as well as members of Family Tree DNA’s own highly respected scientific advisory board.

The schedule of the conference can be found here.  Unfortunately, I was not able to attend the conference this year, although I certainly hope to attend the next conference. 

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Visualizing Your Genetic Genealogy

In my genealogical research, I have sometimes found myself missing the trees by focusing on the forest.  I think it happens to many genealogists – we get caught up in the research, the dates, the places, and we forget that there was so much more to people than their vital statistics.

This can happen to genetic genealogists as well.  The connection between the results of a DNA test and the individuals in our tree can be easy to forget and difficult to visualize.  Take the results of an mtDNA test, for example.  The results are obtained from a tiny piece of DNA that has traveled thousands of years (and often thousands of miles) through hundreds of individuals to end up in your cheek cells and on the tip of a swab.  Everyone’s mtDNA is the product of an amazingly rich story that has largely been lost to history.

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Genetic Testing With 23andMe – Ancestry Testing

Yesterday I posted about my recent testing experience with 23andMe, focusing on the health and traits information.  This post examines the genealogical aspects of testing at 23andMe.

Ancestry Information

Although I was interested in the health and traits information, I was most excited about the ancestral information.  23andMe’s test looks at mtDNA, Y-DNA, and autosomal coverage.  I believe that the company is working to report on ancestry of the X-chromosome, but as I have previously reported X-DNA ancestry can be extremely challenging.

This was my second foray into autosomal DNA testing.  In 2003 I purchased an AncestrybyDNA 2.0 test from DNAPrint Genomics.  The test looked at 71 Ancestry Informative Markers (AIMs) to determine percentages of Indo-European, East-Asian, Native-American, and African ancestry.  It is worth noting that before AncestrybyDNA went out of business (more info here), the company was offering more advanced tests that examined as many as 1,700 markers (still far below the number of markers used to quantify percentages at 23andMe and deCODEme).

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Genetic Testing With 23andMe

This is the first entry in a two-part series describing my recent experiences with genetic testing through 23andMe.  Although I was most excited by the genetic genealogy information provided by the results, I thought that readers might be interested in some of the health and trait information as well.  If I forget to discuss something, feel free to ask in the comments and I’ll do my best to respond.

Note that this discussion is limited to a cursory analysis of my results.  Anyone who is considering testing through 23andMe should be aware that scientists are only just beginning to study and understand the connection between genetics and health, and thus the results are not meant to be interpreted as absolutes.  Be sure to analyze your own results with this caveat in mind, and do your own research into the testing process.

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GeneTree Announces Web Site Out Of Beta

image In October 2007, I wrote about the launch of GeneTree (see “Sorenson Genomic’s GeneTree Launches”), a “DNA-enabled family history-sharing Web site.”  Today, GeneTree has announced that it is out of beta and has added advanced features for users.

Press Release

Following is the press release from GeneTree:

SALT LAKE CITY (March 9, 2009)—GeneTree today announced its free family Web site has completed beta testing and now offers those who sign in a simple, intuitive way to regularly communicate with their extended family and to securely share and store family contact information, personal profiles, photos, video and ancestry documents. Advanced features now available through GeneTree’s redesigned graphic interface include GEDCOM file-format import for family tree collaboration, paternal line genetic genealogy and an all-new family tree building tool.

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Interviews with 23andMe Customers

Image representing 23andMe as depicted in Crun...

Image via CrunchBase

DAVIDE at the European Genetics and Anthropology Blog recently posted two interviews (here and here) with customers of 23andMe’s large-scale genome scanning service, one from Finland and one from the U.S.

It’s very interesting to see the responses of these anonymous individuals, particularly since they are from different countries.

For example, both were asked why they decided to purchase the 23andMe test – “Was it to test your ancestry or genetic health risk factors?”  Interestingly, for both individuals ancestry was the motivating factor behind testing.  More support for my conclusion that these companies should strongly promote the ancestral aspects of their products.

Other Questions

Here are a few examples of other questions in the interviews:

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DNAPrint Genomics Ceases Operations

dnaprintgIn February, I received a number of comments and emails which suggested that DNAPrint Genomics was not processing results and could not be reached by telephone.  DNAPrint was one of the first companies to offer ‘large-scale’ autosomal testing, although their tests were unable to compete with the testing currently offered by companies like 23andMe and deCODEme.

Indeed, the company has recently ceased operations.  From the site: “DNAPrint® Genomics, Inc. has regrettably ceased operations. We thank you for your support.”  As I wrote last February, the company was scheduled to be purchased by Nanobac Pharmaceuticals, but the deal fell through shortly thereafter.

GenomeWeb Announces DNAPrint’s Demise

From an announcement today at GenomeWeb – “DNAPrint Genomics Goes Bust”:

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Spending Time on Facebook

Image representing Facebook as depicted in Cru...

Image via CrunchBase

This isn’t about genetic genealogy or even genealogy, but it’s too interesting to pass up.

A recent Fortune article titled “How Facebook is taking over our lives” points out that roughly 175 million people are members of Facebook, and that the total daily use of Facebook is over 3 billion minutes.

Here are some rough calculations using that 3 billion minutes per day value (and feel free to check my math, please!):  three billion minutes equals 50 million hours, which equals 2.08 million days, which equals 5,707 years.

Thus, every single day humanity spends the equivalent of over 5,000 years on Facebook!

Article Discussing Genetic Genealogy in the Los Angeles Times

mtDNA-based chart of large human migrations.

Image via Wikipedia

In “Called back to Africa by DNA,” journalist Teresa Watanabe highlights the recent surge of interest in the genetic genealogy by African Americans.  This increased interest is often written about during February, which is Black History Month (see “Genetic Genealogy and Black History Month” from February 2008 and “DNA Testing Jumps During Black History Month” from February 2007).  Although the LA times article rehashes some of the same issues, it also contributes a number of new points to the conversation.

Interesting Tidbits:

Among other things, the article mentions several of the projects that focus on African American genetic genealogy, including African Ancestry:

The curiosity has fueled the growth of DNA testing outfits. African Ancestry Inc., a Washington-based firm, has tested the DNA of 15,000 people against its database of 25,000 African genetic lineages, according to its president, Gina M. Paige. The firm’s clients include Winfrey, film director Spike Lee, musician Quincy Jones, comedian Whoopi Goldberg and actors Morgan Freeman and Don Cheadle.

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